There are a number of possibilities to consider. There are adverse reactions to vaccines. Typically these are very rare and can be more severe than what you are describing. Mild reactions can include lack of appetite, slight fever and transient diarrhea. The benefits of vaccination far outweigh the risks and the fact that your puppy had the initial series of vaccinations may be helping him combat a potential threat even now. . In any case it sounds like your puppy is having a mild reaction. You should contact your veterinarian and get his advice as soon as possible. I'm sure he would want to know about any potential complications following a visit.
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